Interactions médicamenteuses
Diphenoxylate-atropine + Revefenacin
Gravité: Modérée
Diphenoxylate-atropine and Revefenacin: moderate interaction.
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Résumé
Revefenacin is an inhaled long-acting antimuscarinic with low systemic exposure, and atropine adds systemic anticholinergic activity. The combination may increase dry mouth, urinary retention, constipation and other anticholinergic effects.
Ce que signifie cette interaction, en termes simples
Diphenoxylate-atropine and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Revefenacin belongs to Respiratory.
Pourquoi elle survient
Additive antimuscarinic effects.
Conduite à tenir
Monitor for anticholinergic effects such as urinary retention, constipation and dry mouth. Limit the duration of diphenoxylate-atropine.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contre-indiquée
- Diphenoxylate-atropine + Phenelzine Contre-indiquée
- Diphenoxylate-atropine + Tranylcypromine Contre-indiquée
- Alfentanil + Diphenoxylate-atropine Majeure
- Alvimopan + Diphenoxylate-atropine Majeure
- Amitriptyline + Diphenoxylate-atropine Majeure
Autres interactions de Revefenacin
- Cyclosporin + Revefenacin Majeure
- Indacaterol-glycopyrronium + Revefenacin Majeure
- Revefenacin + Rifampicin Majeure
- Revefenacin + Tiotropium Majeure
- Atropine + Revefenacin Modérée
- Benztropine + Revefenacin Modérée
Questions fréquentes
Can I take Diphenoxylate-atropine with Revefenacin?
MediHelp rates the interaction as moderate. Diphenoxylate-atropine and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Revefenacin is an inhaled long-acting antimuscarinic with low systemic exposure, and atropine adds systemic anticholinergic activity. The combination may increase dry mouth, urinary retention, constipation and other anticholinergic effects.
How serious is the interaction between Diphenoxylate-atropine and Revefenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, constipation and dry mouth. Limit the duration of diphenoxylate-atropine.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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