Interactions médicamenteuses
Elagolix + Ethinyl estradiol-levonorgestrel
Gravité: Majeure
Elagolix and Ethinyl estradiol-levonorgestrel: major interaction.
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Résumé
Elagolix suppresses the hypothalamic-pituitary-ovarian axis, and estrogen-containing contraceptives are expected to oppose its effect and reduce its efficacy. Elagolix is also not a reliable contraceptive when combined with hormonal methods, and its own effect on contraceptive efficacy is uncertain.
Ce que signifie cette interaction, en termes simples
Elagolix and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Pourquoi elle survient
Pharmacodynamic antagonism between exogenous estrogen/progestin and GnRH receptor antagonism by elagolix.
Conduite à tenir
Avoid combining the two drugs and use non-hormonal contraception during elagolix and for about one week after stopping. Reassess symptom control if hormonal contraception is considered necessary.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contre-indiquée
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contre-indiquée
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Majeure
- Amobarbital + Ethinyl estradiol-levonorgestrel Majeure
- Anastrozole + Ethinyl estradiol-levonorgestrel Majeure
Autres interactions de Elagolix
- Cyclosporin + Elagolix Contre-indiquée
- Elagolix + Gemfibrozil Contre-indiquée
- Desogestrel-ethinyl estradiol + Elagolix Majeure
- Elagolix + Erythromycin Majeure
- Elagolix + Ethinyl estradiol-drospirenone Majeure
- Elagolix + Ketoconazole Majeure
Questions fréquentes
Can I take Elagolix with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as major. Elagolix and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Elagolix suppresses the hypothalamic-pituitary-ovarian axis, and estrogen-containing contraceptives are expected to oppose its effect and reduce its efficacy. Elagolix is also not a reliable contraceptive when combined with hormonal methods, and its own effect on contraceptive efficacy is uncertain.
How serious is the interaction between Elagolix and Ethinyl estradiol-levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two drugs and use non-hormonal contraception during elagolix and for about one week after stopping. Reassess symptom control if hormonal contraception is considered necessary.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
