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Interactions médicamenteuses

Elagolix + Erythromycin

Gravité: Majeure

Elagolix and Erythromycin: major interaction.

Dernière mise à jour

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Résumé

Erythromycin may increase elagolix exposure, raising the risk of adverse effects such as bone loss and liver enzyme elevations. Elagolix labeling restricts use with strong OATP1B1 inhibitors, and erythromycin has inhibitory activity on this transporter.

Ce que signifie cette interaction, en termes simples

Elagolix and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Elagolix belongs to Musculoskeletal; Erythromycin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of OATP1B1-mediated hepatic uptake (and CYP3A) increases elagolix concentrations.

Conduite à tenir

Avoid the combination where possible; use an alternative antibiotic such as azithromycin or doxycycline as appropriate. If unavoidable, limit duration and monitor for adverse effects.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Elagolix with Erythromycin?

MediHelp rates the interaction as major. Elagolix and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin may increase elagolix exposure, raising the risk of adverse effects such as bone loss and liver enzyme elevations. Elagolix labeling restricts use with strong OATP1B1 inhibitors, and erythromycin has inhibitory activity on this transporter.

How serious is the interaction between Elagolix and Erythromycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; use an alternative antibiotic such as azithromycin or doxycycline as appropriate. If unavoidable, limit duration and monitor for adverse effects.

What other medicines interact with Erythromycin?

MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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