Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Fluconazole + Lomitapide

Gravité: Contre-indiquée

Fluconazole and Lomitapide: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Lomitapide is a CYP3A4 substrate, and fluconazole, a moderate CYP3A4 inhibitor, can raise its levels several-fold. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors with lomitapide.

Ce que signifie cette interaction, en termes simples

Fluconazole and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fluconazole belongs to Anti Fungals; Lomitapide belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Fluconazole inhibits CYP3A4, reducing the metabolism of lomitapide.

Conduite à tenir

Do not combine them. If antifungal therapy is needed, use a non-CYP3A4-inhibiting alternative or hold lomitapide during a short course.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Fluconazole et Lomitapide, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Fluconazole with Lomitapide?

MediHelp rates the interaction as contraindicated. Fluconazole and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomitapide is a CYP3A4 substrate, and fluconazole, a moderate CYP3A4 inhibitor, can raise its levels several-fold. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors with lomitapide.

How serious is the interaction between Fluconazole and Lomitapide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine them. If antifungal therapy is needed, use a non-CYP3A4-inhibiting alternative or hold lomitapide during a short course.

What other medicines interact with Fluconazole?

MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter