Drug interactions
Fluconazole + Lomitapide
Severity: Contraindicated
Fluconazole and Lomitapide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a CYP3A4 substrate, and fluconazole, a moderate CYP3A4 inhibitor, can raise its levels several-fold. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors with lomitapide.
What this interaction means in plain words
Fluconazole and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Lomitapide belongs to Cardiovascular.
Why it happens
Fluconazole inhibits CYP3A4, reducing the metabolism of lomitapide.
What to do
Do not combine them. If antifungal therapy is needed, use a non-CYP3A4-inhibiting alternative or hold lomitapide during a short course.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Fluconazole with Lomitapide?
MediHelp rates the interaction as contraindicated. Fluconazole and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomitapide is a CYP3A4 substrate, and fluconazole, a moderate CYP3A4 inhibitor, can raise its levels several-fold. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Labeling contraindicates moderate and strong CYP3A4 inhibitors with lomitapide.
How serious is the interaction between Fluconazole and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine them. If antifungal therapy is needed, use a non-CYP3A4-inhibiting alternative or hold lomitapide during a short course.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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