Interactions médicamenteuses
Fluorouracil + Leucovorin
Gravité: Majeure
Fluorouracil and Leucovorin: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Leucovorin is deliberately combined with fluorouracil to enhance its cytotoxic effect, but it also increases fluorouracil toxicity, particularly diarrhea, mucositis and myelosuppression. Severe gastrointestinal toxicity can be dangerous, especially in older patients.
Ce que signifie cette interaction, en termes simples
Fluorouracil and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluorouracil belongs to Oncology; Leucovorin belongs to Miscellaneous.
Pourquoi elle survient
Leucovorin supplies reduced folate that stabilizes the binding of fluorodeoxyuridylate to thymidylate synthase, enhancing both efficacy and toxicity.
Conduite à tenir
Use established regimen doses of fluorouracil when combined with leucovorin and monitor blood counts and for diarrhea and mucositis. Interrupt therapy and reduce the dose for significant toxicity.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Fluorouracil
Autres interactions de Leucovorin
- Capecitabine + Leucovorin Majeure
- Glucarpidase + Leucovorin Majeure
- Leucovorin + Phenobarbitone Modérée
- Leucovorin + Phenytoin Modérée
Questions fréquentes
Can I take Fluorouracil with Leucovorin?
MediHelp rates the interaction as major. Fluorouracil and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leucovorin is deliberately combined with fluorouracil to enhance its cytotoxic effect, but it also increases fluorouracil toxicity, particularly diarrhea, mucositis and myelosuppression. Severe gastrointestinal toxicity can be dangerous, especially in older patients.
How serious is the interaction between Fluorouracil and Leucovorin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use established regimen doses of fluorouracil when combined with leucovorin and monitor blood counts and for diarrhea and mucositis. Interrupt therapy and reduce the dose for significant toxicity.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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