Interactions médicamenteuses
Leucovorin + Phenytoin
Gravité: Modérée
Leucovorin and Phenytoin: moderate interaction.
Dernière mise à jour
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Résumé
Folinic acid may reduce phenytoin levels and anticonvulsant effect, raising the risk of breakthrough seizures. Folate also has been reported to lower phenytoin concentrations.
Ce que signifie cette interaction, en termes simples
Leucovorin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leucovorin belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Pourquoi elle survient
Folate may increase phenytoin metabolism; a pro-convulsant effect has also been proposed.
Conduite à tenir
Monitor seizure control and phenytoin plasma concentrations during and after leucovorin treatment, adjusting the dose as needed.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Leucovorin
- Capecitabine + Leucovorin Majeure
- Fluorouracil + Leucovorin Majeure
- Glucarpidase + Leucovorin Majeure
- Leucovorin + Phenobarbitone Modérée
Autres interactions de Phenytoin
- Artemether / lumefantrine + Phenytoin Contre-indiquée
- Bictegravir + Phenytoin Contre-indiquée
- Cabotegravir + Phenytoin Contre-indiquée
- Doravirine + Phenytoin Contre-indiquée
- Elbasvir / grazoprevir + Phenytoin Contre-indiquée
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contre-indiquée
Questions fréquentes
Can I take Leucovorin with Phenytoin?
MediHelp rates the interaction as moderate. Leucovorin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folinic acid may reduce phenytoin levels and anticonvulsant effect, raising the risk of breakthrough seizures. Folate also has been reported to lower phenytoin concentrations.
How serious is the interaction between Leucovorin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and phenytoin plasma concentrations during and after leucovorin treatment, adjusting the dose as needed.
What other medicines interact with Leucovorin?
MediHelp also lists interactions of Leucovorin with, for example, Capecitabine, Fluorouracil, Glucarpidase. The full list is on the Leucovorin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
