Interactions médicamenteuses
Insulin degludec + Rosiglitazone
Gravité: Majeure
Insulin degludec and Rosiglitazone: major interaction.
Dernière mise à jour
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Résumé
Rosiglitazone improves insulin sensitivity and enhances insulin's glucose-lowering effect, increasing hypoglycemia risk. Combination with insulin has also been associated with fluid retention, heart failure and possibly myocardial ischemia.
Ce que signifie cette interaction, en termes simples
Insulin degludec and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Pourquoi elle survient
Additive glucose lowering from insulin sensitization plus exogenous insulin; fluid retention is also additive.
Conduite à tenir
Monitor blood glucose and reduce the insulin dose as needed. Monitor for edema and heart failure signs, and avoid in patients with heart failure or high cardiovascular risk.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Insulin degludec
Autres interactions de Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Majeure
- Insulin aspart-insulin aspart protamine + Rosiglitazone Majeure
- Insulin aspart + Rosiglitazone Majeure
- Insulin degludec / insulin aspart + Rosiglitazone Majeure
- Insulin degludec-insulin aspart + Rosiglitazone Majeure
- Insulin degludec-liraglutide + Rosiglitazone Majeure
Questions fréquentes
Can I take Insulin degludec with Rosiglitazone?
MediHelp rates the interaction as major. Insulin degludec and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone improves insulin sensitivity and enhances insulin's glucose-lowering effect, increasing hypoglycemia risk. Combination with insulin has also been associated with fluid retention, heart failure and possibly myocardial ischemia.
How serious is the interaction between Insulin degludec and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose as needed. Monitor for edema and heart failure signs, and avoid in patients with heart failure or high cardiovascular risk.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
