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Interactions médicamenteuses

Isavuconazole + Ritonavir

Gravité: Contre-indiquée

Isavuconazole and Ritonavir: contraindicated interaction.

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Résumé

High-dose ritonavir can induce metabolism of isavuconazole and lower its exposure, whereas lower doses act as a CYP3A4 inhibitor and may raise it. The net effect depends on dose and can compromise efficacy or increase toxicity.

Ce que signifie cette interaction, en termes simples

Isavuconazole and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isavuconazole belongs to Anti Fungals; Ritonavir belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Dose-dependent mixed CYP3A4 effects of ritonavir; high doses induce isavuconazole clearance.

Conduite à tenir

Avoid high-dose ritonavir with isavuconazole. With low-dose boosting, monitor isavuconazole levels, response and adverse effects.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isavuconazole with Ritonavir?

MediHelp rates the interaction as contraindicated. Isavuconazole and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. High-dose ritonavir can induce metabolism of isavuconazole and lower its exposure, whereas lower doses act as a CYP3A4 inhibitor and may raise it. The net effect depends on dose and can compromise efficacy or increase toxicity.

How serious is the interaction between Isavuconazole and Ritonavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose ritonavir with isavuconazole. With low-dose boosting, monitor isavuconazole levels, response and adverse effects.

What other medicines interact with Isavuconazole?

MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.

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