Interactions médicamenteuses
Ixekizumab + Quinidine
Gravité: Mineure
Ixekizumab and Quinidine: minor interaction.
Dernière mise à jour
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Résumé
Chronic inflammation can suppress CYP450 enzymes, and control of inflammation with IL-17A blockade may restore their activity. Quinidine has a narrow therapeutic index, so changes in its metabolism could matter. The effect is theoretical and probably small.
Ce que signifie cette interaction, en termes simples
Ixekizumab and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
Pourquoi elle survient
Cytokine normalization after IL-17A inhibition may restore CYP3A4 activity and modestly reduce quinidine exposure.
Conduite à tenir
When ixekizumab is started or stopped, check the quinidine response, ECG and serum concentration if clinically indicated. Adjust the quinidine dose only if the response or level changes.
Questions à poser à votre pharmacien
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Autres interactions de Quinidine
- Adagrasib + Quinidine Contre-indiquée
- Arsenic trioxide + Quinidine Contre-indiquée
- Artemether / lumefantrine + Quinidine Contre-indiquée
- Chloroquine + Quinidine Contre-indiquée
- Dofetilide + Quinidine Contre-indiquée
- Dronedarone + Quinidine Contre-indiquée
Autres interactions de Ixekizumab
- Ixekizumab + Measles mumps and rubella vaccine Majeure
- Ixekizumab + Upadacitinib Majeure
- Ifosfamide + Ixekizumab Modérée
- Ixekizumab + Lomustine Modérée
- Carbamazepine + Ixekizumab Mineure
- Cyclosporin + Ixekizumab Mineure
Questions fréquentes
Can I take Ixekizumab with Quinidine?
MediHelp rates the interaction as minor. Ixekizumab and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation can suppress CYP450 enzymes, and control of inflammation with IL-17A blockade may restore their activity. Quinidine has a narrow therapeutic index, so changes in its metabolism could matter. The effect is theoretical and probably small.
How serious is the interaction between Ixekizumab and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When ixekizumab is started or stopped, check the quinidine response, ECG and serum concentration if clinically indicated. Adjust the quinidine dose only if the response or level changes.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
