Référentiel des médicaments
Ixekizumab
Ixekizumab is a medicine in the class miscellaneous. It is used for ankylosing spondylitis.
- Classe médicamenteuse: Miscellaneous
- Indications: ankylosing spondylitis
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- L04AC13
- Formes courantes
- injection
- Dosages courants
- 80 mg/ml
- Interactions connues
- 13 (Majeure: 2 · Modérée: 2 · Mineure: 9)
- Noms commerciaux
- 5
- Pays et marchés
- 5
Indications
Mécanisme d'action
Humanized monoclonal IgG4 antibody that targets interleukin-17A (IL-17A) and neutralizes the proinflammatory effects of IL-17A
Posologie adulte habituelle (résumé de la notice)
Psoriasis (Week 0): 160 mg SC (two 80-mg injections), THEN Weeks 2, 4, 6, 8, 10, and 12: 80 mg SC q2Weeks, THEN Week 16 and thereafter: 80 mg SC q4Weeks
Grossesse et allaitement
- Grossesse
- Unknown Human IgG is known to cross the placental barrier; therefore, the drug may be transmitted from the mother to the developing fetus
- Allaitement
- Unknown There are no available data on presence of this drug in human milk, effects on breastfed infant, or on milk production; the drug was detected in the milk of lactating cynomolgus monkeys; when a drug is present in animal milk, it is likely that the drug will be present in human milk
Effets indésirables signalés
- Tinea infections
- Serious infections
- Upper respiratory tract infections
- Injection site reacation
- Thrombocytopenia
- Nausea
Contre-indications
- Hypersensitivity reaction (eg, anaphylaxis) to drug or excipients
Précautions particulières
- Patients receiving treatment may be at increased risk of inflammatory bowel disease; in clinical trials, Crohn’s disease and ulcerative colitis, including exacerbations, occurred at a greater frequency in treated group than placebo control group; during treatment, monitor for onset or exacerbation of inflammatory bowel disease and if IBD occurs...
- ... discontinue therapy and initiate appropriate medical management
- Prior to initiating drug, consider completion of all age-appropriate immunizations; avoid use of live vaccines; no data are available on the response to live vaccines while taking ixekizumab
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (13)
- Ixekizumab + Measles mumps and rubella vaccine Major
- Ixekizumab + Upadacitinib Major
- Ifosfamide + Ixekizumab Moderate
- Ixekizumab + Lomustine Moderate
- Carbamazepine + Ixekizumab Minor
- Cyclosporin + Ixekizumab Minor
- Ethosuximide + Ixekizumab Minor
- Ixekizumab + Phenytoin Minor
- Ixekizumab + Pneumococcal vaccine 13-valent Minor
- Ixekizumab + Quinidine Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Ixekizumab used for?
Ixekizumab is a medicine in the class miscellaneous. It is used for Ankylosing spondylitis, Psoriasis, Psoriatic arthritis, Spondyloarthritis.
What side effects have been reported with Ixekizumab?
Tinea infections, Serious infections, Upper respiratory tract infections, Injection site reacation, Thrombocytopenia, Nausea.
Can Ixekizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Human IgG is known to cross the placental barrier; therefore, the drug may be transmitted from the mother to the developing fetus Breastfeeding: Unknown. There are no available data on presence of this drug in human milk, effects on breastfed infant, or on milk production; the drug was detected in the milk of lactating cynomolgus monkeys; when a drug is present in animal milk, it is likely that the drug will be present in human milk
What does Ixekizumab interact with?
MediHelp lists 13 known interactions for Ixekizumab. Major: 2 · Moderate: 2 · Minor: 9. The most serious include Measles mumps and rubella vaccine, Upadacitinib, Ifosfamide.
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