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Interactions médicamenteuses

Levothyroxine + Sodium polystyrene sulfonate

Gravité: Modérée

Levothyroxine and Sodium polystyrene sulfonate: moderate interaction.

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Résumé

Sodium polystyrene sulfonate can bind oral levothyroxine in the gut and reduce its absorption. This may lower thyroid hormone exposure and lead to hypothyroidism over time.

Ce que signifie cette interaction, en termes simples

Levothyroxine and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Levothyroxine belongs to Endocrine; Sodium polystyrene sulfonate belongs to Miscellaneous.

Niveau de preuve: Low

Pourquoi elle survient

Binding of levothyroxine in the gastrointestinal tract by the resin reduces its absorption.

Conduite à tenir

Give levothyroxine at least 3 hours apart from sodium polystyrene sulfonate. Monitor TSH and adjust the levothyroxine dose if needed.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Levothyroxine with Sodium polystyrene sulfonate?

MediHelp rates the interaction as moderate. Levothyroxine and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium polystyrene sulfonate can bind oral levothyroxine in the gut and reduce its absorption. This may lower thyroid hormone exposure and lead to hypothyroidism over time.

How serious is the interaction between Levothyroxine and Sodium polystyrene sulfonate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give levothyroxine at least 3 hours apart from sodium polystyrene sulfonate. Monitor TSH and adjust the levothyroxine dose if needed.

What other medicines interact with Levothyroxine?

MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.

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