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Interactions médicamenteuses

Linezolid + Naratriptan

Gravité: Majeure

Linezolid and Naratriptan: major interaction.

Dernière mise à jour

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Résumé

Linezolid's MAO-inhibiting activity combined with a triptan raises the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO, so its exposure rise is limited, but the serotonergic concern remains.

Ce que signifie cette interaction, en termes simples

Linezolid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Linezolid belongs to Anti Bacterial; Naratriptan belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Additive serotonergic effect from MAO inhibition and 5-HT1B/1D agonism.

Conduite à tenir

Avoid the combination where possible and use non-serotonergic acute migraine treatment during linezolid therapy; if used together, monitor for agitation, tremor, hyperthermia and clonus.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Linezolid with Naratriptan?

MediHelp rates the interaction as major. Linezolid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid's MAO-inhibiting activity combined with a triptan raises the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO, so its exposure rise is limited, but the serotonergic concern remains.

How serious is the interaction between Linezolid and Naratriptan?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use non-serotonergic acute migraine treatment during linezolid therapy; if used together, monitor for agitation, tremor, hyperthermia and clonus.

What other medicines interact with Linezolid?

MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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