Interactions médicamenteuses
Valoctocogene roxaparvovec + Valproic acid
Gravité: Majeure
Valoctocogene roxaparvovec and Valproic acid: major interaction.
Dernière mise à jour
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Résumé
Valoctocogene roxaparvovec commonly causes transaminase elevations, and valproate is also hepatotoxic. Concurrent use may increase liver injury and may reduce the response to gene therapy.
Ce que signifie cette interaction, en termes simples
Valoctocogene roxaparvovec and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Valoctocogene roxaparvovec belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
Pourquoi elle survient
Additive hepatotoxicity from two hepatotoxic agents.
Conduite à tenir
Monitor liver enzymes frequently after infusion and consider an alternative anticonvulsant if feasible. Manage any transaminase rise according to the gene therapy protocol.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Valproic acid
- Ertapenem + Valproic acid Contre-indiquée
- Imipenem / cilastatin / relebactam + Valproic acid Contre-indiquée
- Imipenem / cilastatin + Valproic acid Contre-indiquée
- Meropenem / vaborbactam + Valproic acid Contre-indiquée
- Meropenem + Valproic acid Contre-indiquée
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Majeure
Autres interactions de Valoctocogene roxaparvovec
Questions fréquentes
Can I take Valoctocogene roxaparvovec with Valproic acid?
MediHelp rates the interaction as major. Valoctocogene roxaparvovec and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec commonly causes transaminase elevations, and valproate is also hepatotoxic. Concurrent use may increase liver injury and may reduce the response to gene therapy.
How serious is the interaction between Valoctocogene roxaparvovec and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes frequently after infusion and consider an alternative anticonvulsant if feasible. Manage any transaminase rise according to the gene therapy protocol.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
