Interactions médicamenteuses
Allopurinol + Valoctocogene roxaparvovec
Gravité: Modérée
Allopurinol and Valoctocogene roxaparvovec: moderate interaction.
Dernière mise à jour
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Résumé
Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly causes ALT elevations. Hepatotoxic drugs, including allopurinol which can occasionally cause hepatitis, may increase the risk of liver injury and confound interpretation of enzyme rises.
Ce que signifie cette interaction, en termes simples
Allopurinol and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Valoctocogene roxaparvovec belongs to Miscellaneous.
Pourquoi elle survient
Additive hepatotoxic potential in a liver transduced by AAV gene therapy; no pharmacokinetic mechanism is established.
Conduite à tenir
Monitor ALT regularly after infusion as per product labeling and review necessity of allopurinol. Consider alternatives if liver enzymes rise.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Allopurinol
- Allopurinol + Azathioprine Majeure
- Allopurinol + Didanosine Majeure
- Allopurinol + Mercaptopurine Majeure
- Allopurinol + Pexidartinib Majeure
- Allopurinol + Amlodipine-benazepril Modérée
- Allopurinol + Amlodipine-perindopril Modérée
Autres interactions de Valoctocogene roxaparvovec
Questions fréquentes
Can I take Allopurinol with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Allopurinol and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly causes ALT elevations. Hepatotoxic drugs, including allopurinol which can occasionally cause hepatitis, may increase the risk of liver injury and confound interpretation of enzyme rises.
How serious is the interaction between Allopurinol and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT regularly after infusion as per product labeling and review necessity of allopurinol. Consider alternatives if liver enzymes rise.
What other medicines interact with Allopurinol?
MediHelp also lists interactions of Allopurinol with, for example, Azathioprine, Didanosine, Mercaptopurine. The full list is on the Allopurinol page.
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