Riferimento farmaci
Diroximel fumarate
Diroximel fumarate is a medicine in the class central nervous system. It is used for multiple sclerosis.
- Classe del farmaco: Central Nervous System
- Indicato per: multiple sclerosis
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Central Nervous System
- Codice ATC
- L04AX07
- Forme farmaceutiche comuni
- capsula
- Dosaggi comuni
- 231 mg
- Interazioni note
- 1 (Controindicata: 1)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
The mechanism in multiple sclerosis is unknown. The active metabolite MMF activates the Nrf2 pathway (cellular response to oxidative stress) and is a nicotinic acid receptor agonist in vitro.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Relapsing forms of multiple sclerosis: starting dose 231 mg orally twice a day for 7 days, then maintenance dose 462 mg (two 231 mg capsules) orally twice a day.
Gravidanza e allattamento
- Gravidanza
- Unknown Human data come mainly from dimethyl fumarate (same active metabolite): registry data show no rise in birth defects. In rabbits it caused skeletal malformations at higher doses. Use only if clearly needed; a pregnancy registry exists.
- Allattamento
- Safe No direct data, but with dimethyl fumarate the active metabolite reaches milk in low amounts, with no harm in over 20 infants. LactMed: acceptable, at least after 1 month of age. Monitor infant weight gain.
Effetti indesiderati segnalati
- Flushing
- Abdominal pain
- Diarrhea
- Nausea
- Vomiting
- Pruritus
Controindicazioni
- Known hypersensitivity to diroximel fumarate, dimethyl fumarate, or any excipient (reactions may include anaphylaxis and angioedema).
- Co-administration with dimethyl fumarate.
Chi deve prestare attenzione
- Anaphylaxis and angioedema can occur after the first dose or at any time; discontinue and do not restart.
- PML has occurred with dimethyl fumarate (same active metabolite); withhold at the first sign or symptom suggestive of PML.
- Herpes zoster and other serious opportunistic infections can occur; consider withholding treatment until the infection resolves.
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Interazioni principali (1)
- Dimethyl fumarate + Diroximel fumarate Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Diroximel fumarate used for?
Diroximel fumarate is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Diroximel fumarate?
Flushing, Abdominal pain, Diarrhea, Nausea, Vomiting, Pruritus.
Can Diroximel fumarate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Human data come mainly from dimethyl fumarate (same active metabolite): registry data show no rise in birth defects. In rabbits it caused skeletal malformations at higher doses. Use only if clearly needed; a pregnancy registry exists. Breastfeeding: Safe. No direct data, but with dimethyl fumarate the active metabolite reaches milk in low amounts, with no harm in over 20 infants. LactMed: acceptable, at least after 1 month of age. Monitor infant weight gain.
What does Diroximel fumarate interact with?
MediHelp lists 1 known interactions for Diroximel fumarate. Contraindicated: 1. The most serious include Dimethyl fumarate.
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