Riferimento farmaci
Interferon beta 1a
Interferon beta 1a is a medicine in the class central nervous system. It is used for multiple sclerosis.
- Classe del farmaco: Central Nervous System
- Indicato per: multiple sclerosis
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Central Nervous System
- Codice ATC
- L03AB07
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 30 mcg/.5 ml, 22 mcg/0.5 ml, 30 mcg
- Interazioni note
- 18 (Maggiore: 9 · Moderata: 8 · Minore: 1)
- Nomi commerciali
- 10
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Recombinant interferon; antiviral, antiproliferative, immunoregulatory protein; alters response to surface antigen and may enhance immune cell activities
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Avonex: 30 mcg IM qWk, starting with 7.5 mcg IM for first week, to reduce flu-like symptoms; increase by 7.5 mcg/week for next 3 weeks until recommended dose of 30 mcg/week
Gravidanza e allattamento
- Gravidanza
- Safe Registry and cohort data (over 1000 pregnancies) show no rise in major birth defects; miscarriage data are inconsistent, and high doses caused miscarriage in monkeys. EU label: may be considered in pregnancy if clinically needed. Plan treatment with the MS specialist.
- Allattamento
- Safe Milk levels are negligible and it is poorly absorbed by mouth. EU label: can be used while breastfeeding. LactMed: many breastfed infants without adverse effects; a preferred MS treatment while nursing, and feeds can resume right after an injection.
Effetti indesiderati segnalati
- Headache
- Nausea
- Injection site reactions
- Flu-like syndrome
- Muscle ache
- URT infection
Chi deve prestare attenzione
- Thyroid function should be monitored periodically If patients have or develop symptoms of thyroid dysfunction (hypo- or hyperthyroidism),
- Seizures have been temporally associated with use of beta interferons in clinical trials and postmarketing safety surveillance
- Cases of thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, some fatal, have been reported
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (18)
- Deferiprone + Interferon beta 1a Major
- Etrasimod + Interferon beta 1a Major
- Hydroxyurea + Interferon beta 1a Major
- Idecabtagene vicleucel + Interferon beta 1a Major
- Interferon beta 1a + Lisocabtagene maraleucel Major
- Interferon beta 1a + Pexidartinib Major
- Interferon beta 1a + Pretomanid Major
- Interferon beta 1a + Ropeginterferon alfa 2b Major
- Interferon beta 1a + Tisagenlecleucel Major
- Acalabrutinib + Interferon beta 1a Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Interferon beta 1a used for?
Interferon beta 1a is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Interferon beta 1a?
Headache, Nausea, Injection site reactions, Flu-like syndrome, Muscle ache, URT infection.
Can Interferon beta 1a be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Registry and cohort data (over 1000 pregnancies) show no rise in major birth defects; miscarriage data are inconsistent, and high doses caused miscarriage in monkeys. EU label: may be considered in pregnancy if clinically needed. Plan treatment with the MS specialist. Breastfeeding: Safe. Milk levels are negligible and it is poorly absorbed by mouth. EU label: can be used while breastfeeding. LactMed: many breastfed infants without adverse effects; a preferred MS treatment while nursing, and feeds can resume right after an injection.
What does Interferon beta 1a interact with?
MediHelp lists 18 known interactions for Interferon beta 1a. Major: 9 · Moderate: 8 · Minor: 1. The most serious include Deferiprone, Etrasimod, Hydroxyurea.
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