Riferimento farmaci
Dimethyl fumarate
Dimethyl fumarate is a medicine in the class central nervous system. It is used for multiple sclerosis.
- Classe del farmaco: Central Nervous System
- Indicato per: multiple sclerosis
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Central Nervous System
- Codice ATC
- L04AX07
- Forme farmaceutiche comuni
- capsula
- Dosaggi comuni
- 120 mg, 240 mg
- Interazioni note
- 1 (Controindicata: 1)
- Nomi commerciali
- 24
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
Exact mechanism is unknown Methyl ester of fumaric acid that elicits immunomodulatory effects Dimethyl fumarate and the metabolite (monomethyl fumarate [MMF]) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, a transcription factor encoded by the NFE2L2 gene
Dose abituale nell'adulto (sintesi del foglio illustrativo)
120 mg PO BID initially; after 7 days, increase to maintenance dose of 240 mg BID
Gravidanza e allattamento
- Gravidanza
- Unknown Registry data (over 360 births) show no rise in birth defects or miscarriage; animal studies showed reproductive toxicity. EU label: use in pregnancy only if clearly needed. It is short-acting and is often stopped when pregnancy is planned or confirmed.
- Allattamento
- Safe Its active form (monomethyl fumarate) reaches milk in low amounts; data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. EU label: weigh breastfeeding against treatment. Monitor infant weight gain.
Effetti indesiderati segnalati
- Vomiting
- Diarrhea
- Nausea
- Abdominal pain
- Rash
- Pruritus
Chi deve prestare attenzione
- Progressive multifocal leukoencephalopathy (PML) resulting in death, in the postmarketing setting have occurred
- Do not restart therapy if anaphylaxis or angioedema occur
- Clinically significant cases of liver injury reported; onset ranged from a few days to several months after treatment initiation;
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (1)
- Dimethyl fumarate + Diroximel fumarate Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Dimethyl fumarate used for?
Dimethyl fumarate is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Dimethyl fumarate?
Vomiting, Diarrhea, Nausea, Abdominal pain, Rash, Pruritus.
Can Dimethyl fumarate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Registry data (over 360 births) show no rise in birth defects or miscarriage; animal studies showed reproductive toxicity. EU label: use in pregnancy only if clearly needed. It is short-acting and is often stopped when pregnancy is planned or confirmed. Breastfeeding: Safe. Its active form (monomethyl fumarate) reaches milk in low amounts; data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. EU label: weigh breastfeeding against treatment. Monitor infant weight gain.
What does Dimethyl fumarate interact with?
MediHelp lists 1 known interactions for Dimethyl fumarate. Contraindicated: 1. The most serious include Diroximel fumarate.
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