Riferimento farmaci
Monomethyl fumarate
Monomethyl fumarate is a medicine in the class central nervous system. It is used for multiple sclerosis.
- Classe del farmaco: Central Nervous System
- Indicato per: multiple sclerosis
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Central Nervous System
Per cosa si usa
Come agisce
The mechanism in multiple sclerosis is unknown. MMF activates the Nrf2 pathway (response to oxidative stress) and is a nicotinic acid receptor agonist in vitro.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Relapsing forms of multiple sclerosis: starting dose 95 mg orally twice a day for 7 days, then maintenance 190 mg (two 95 mg capsules) orally twice a day.
Gravidanza e allattamento
- Gravidanza
- Unknown Registry data for dimethyl fumarate (its prodrug) show no rise in birth defects or miscarriage; most exposures were in the 1st trimester. In animals, offspring survival, growth and behaviour were affected at clinically relevant doses. Use only if needed.
- Allattamento
- Safe No direct data, but it is the active form of dimethyl fumarate: low milk levels and data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. US label: weigh benefits. Monitor infant weight gain.
Effetti indesiderati segnalati
- Flushing
- Abdominal pain
- Diarrhea
- Nausea
- Vomiting
- Pruritus
Controindicazioni
- Known hypersensitivity to monomethyl fumarate, dimethyl fumarate, diroximel fumarate, or any excipient (reactions may include anaphylaxis or angioedema).
- Concomitant use with dimethyl fumarate or diroximel fumarate.
Chi deve prestare attenzione
- Anaphylaxis and angioedema can occur after the first dose or at any time; discontinue and do not restart.
- PML: withhold at the first sign or symptom suggestive of PML.
- Herpes zoster and other serious opportunistic infections: consider withholding until the infection resolves.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Monomethyl fumarate used for?
Monomethyl fumarate is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Monomethyl fumarate?
Flushing, Abdominal pain, Diarrhea, Nausea, Vomiting, Pruritus.
Can Monomethyl fumarate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Registry data for dimethyl fumarate (its prodrug) show no rise in birth defects or miscarriage; most exposures were in the 1st trimester. In animals, offspring survival, growth and behaviour were affected at clinically relevant doses. Use only if needed. Breastfeeding: Safe. No direct data, but it is the active form of dimethyl fumarate: low milk levels and data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. US label: weigh benefits. Monitor infant weight gain.
What does Monomethyl fumarate interact with?
MediHelp does not list a checked interaction for Monomethyl fumarate yet. Always tell your pharmacist about every medicine you take.
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