Riferimento farmaci
Eluxadoline
Eluxadoline is a medicine in the class gastrointestinal tract. It is used for irritable bowel syndrome.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: irritable bowel syndrome
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Gastrointestinal Tract
- Forme farmaceutiche comuni
- compressa
- Interazioni note
- 111 (Maggiore: 10 · Moderata: 64 · Minore: 37)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Mu-opioid receptor agonist, also a delta opioid receptor antagonist and a kappa opioid receptor agonist. In animals it interacts with opioid receptors in the gut.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
IBS-D: 100 mg orally twice daily with food
Gravidanza e allattamento
- Gravidanza
- Unknown No human studies; no birth defects in rats or rabbits at high exposures. EU label: avoid in pregnancy as a precaution.
- Allattamento
- Unknown No human data; it passes into rat milk. EU label: decide whether to stop breastfeeding or treatment. LactMed: it has opioid activity, so an alternative is preferred, especially with a newborn or preterm infant.
Effetti indesiderati segnalati
- Constipation
- Nausea
- Abdominal pain
- Upper respiratory tract infection
- Vomiting
- Rash
Controindicazioni
- Patients without a gallbladder
- Known or suspected biliary duct obstruction, or sphincter of Oddi disease or dysfunction
- Alcoholism, alcohol abuse or addiction, or more than 3 alcoholic beverages per day
Chi deve prestare attenzione
- Pancreatitis, including fatal cases, mainly in patients without a gallbladder; most serious cases within a week of starting. Evaluate alcohol intake; stop immediately if symptoms occur.
- Sphincter of Oddi spasm; do not restart in patients who developed it or biliary duct obstruction.
- Serious hypersensitivity reactions including anaphylaxis, some after the first one or two doses.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (111)
- Alosetron + Eluxadoline Major
- Atropine + Eluxadoline Major
- Buprenorphine + Eluxadoline Major
- Cyclosporin + Eluxadoline Major
- Diphenoxylate-atropine + Eluxadoline Major
- Eluxadoline + Hydromorphone Major
- Eluxadoline + Loperamide Major
- Eluxadoline + Meperidine Major
- Eluxadoline + Morphine Major
- Eluxadoline + Oxymorphone Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Domande frequenti
What is Eluxadoline used for?
Eluxadoline is a medicine in the class gastrointestinal tract. It is used for Irritable bowel syndrome.
What side effects have been reported with Eluxadoline?
Constipation, Nausea, Abdominal pain, Upper respiratory tract infection, Vomiting, Rash.
Can Eluxadoline be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human studies; no birth defects in rats or rabbits at high exposures. EU label: avoid in pregnancy as a precaution. Breastfeeding: Unknown. No human data; it passes into rat milk. EU label: decide whether to stop breastfeeding or treatment. LactMed: it has opioid activity, so an alternative is preferred, especially with a newborn or preterm infant.
What does Eluxadoline interact with?
MediHelp lists 111 known interactions for Eluxadoline. Major: 10 · Moderate: 64 · Minor: 37. The most serious include Alosetron, Atropine, Buprenorphine.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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