Interazioni tra farmaci
Eluxadoline + Hydromorphone
Gravità: Maggiore
Eluxadoline and Hydromorphone: major interaction.
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Sintesi
Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.
Cosa significa questa interazione in parole semplici
Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eluxadoline belongs to Gastrointestinal Tract; Hydromorphone belongs to Musculoskeletal.
Perché avviene
Additive inhibition of gastrointestinal motility via opioid receptor activity.
Cosa fare
Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Hydromorphone
- Alvimopan + Hydromorphone Controindicata
- Bupropion-naltrexone + Hydromorphone Controindicata
- Hydromorphone + Isocarboxazid Controindicata
- Hydromorphone + Olanzapine / samidorphan Controindicata
- Hydromorphone + Phenelzine Controindicata
- Hydromorphone + Tranylcypromine Controindicata
Altre interazioni di Eluxadoline
- Alosetron + Eluxadoline Maggiore
- Atropine + Eluxadoline Maggiore
- Buprenorphine + Eluxadoline Maggiore
- Cyclosporin + Eluxadoline Maggiore
- Diphenoxylate-atropine + Eluxadoline Maggiore
- Eluxadoline + Loperamide Maggiore
Domande frequenti
Can I take Eluxadoline with Hydromorphone?
MediHelp rates the interaction as major. Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.
How serious is the interaction between Eluxadoline and Hydromorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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