Interazioni tra farmaci
Diphenoxylate-atropine + Eluxadoline
Gravità: Maggiore
Diphenoxylate-atropine and Eluxadoline: major interaction.
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Sintesi
Eluxadoline is an opioid receptor modulator whose labeling warns against use with drugs that cause constipation. Diphenoxylate-atropine is strongly constipating and increases the risk of serious complications such as ileus or obstruction.
Cosa significa questa interazione in parole semplici
Diphenoxylate-atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Eluxadoline belongs to Gastrointestinal Tract.
Perché avviene
Additive inhibition of gastrointestinal motility via opioid and anticholinergic effects.
Cosa fare
Avoid using the two together. If constipation or abdominal pain develops, stop the agents and assess for ileus.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Controindicata
- Diphenoxylate-atropine + Phenelzine Controindicata
- Diphenoxylate-atropine + Tranylcypromine Controindicata
- Alfentanil + Diphenoxylate-atropine Maggiore
- Alvimopan + Diphenoxylate-atropine Maggiore
- Amitriptyline + Diphenoxylate-atropine Maggiore
Altre interazioni di Eluxadoline
- Alosetron + Eluxadoline Maggiore
- Atropine + Eluxadoline Maggiore
- Buprenorphine + Eluxadoline Maggiore
- Cyclosporin + Eluxadoline Maggiore
- Eluxadoline + Hydromorphone Maggiore
- Eluxadoline + Loperamide Maggiore
Domande frequenti
Can I take Diphenoxylate-atropine with Eluxadoline?
MediHelp rates the interaction as major. Diphenoxylate-atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is an opioid receptor modulator whose labeling warns against use with drugs that cause constipation. Diphenoxylate-atropine is strongly constipating and increases the risk of serious complications such as ileus or obstruction.
How serious is the interaction between Diphenoxylate-atropine and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together. If constipation or abdominal pain develops, stop the agents and assess for ileus.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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