Interazioni tra farmaci
Eluxadoline + Morphine
Gravità: Maggiore
Eluxadoline and Morphine: major interaction.
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Sintesi
Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS and is labeled to be avoided with drugs that cause constipation. Morphine's constipating effect may lead to severe constipation or complications such as ileus, and eluxadoline-related pancreatitis risk is also a concern.
Cosa significa questa interazione in parole semplici
Eluxadoline and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eluxadoline belongs to Gastrointestinal Tract; Morphine belongs to Musculoskeletal.
Perché avviene
Additive opioid-receptor-mediated reduction in gastrointestinal motility.
Cosa fare
Avoid the combination; if opioid therapy is needed, stop eluxadoline. Monitor for constipation and abdominal pain if exposure overlaps.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Morphine
- Alvimopan + Morphine Controindicata
- Isocarboxazid + Morphine Controindicata
- Morphine + Olanzapine / samidorphan Controindicata
- Morphine + Phenelzine Controindicata
- Morphine + Tranylcypromine Controindicata
- Alfentanil + Morphine Maggiore
Altre interazioni di Eluxadoline
- Alosetron + Eluxadoline Maggiore
- Atropine + Eluxadoline Maggiore
- Buprenorphine + Eluxadoline Maggiore
- Cyclosporin + Eluxadoline Maggiore
- Diphenoxylate-atropine + Eluxadoline Maggiore
- Eluxadoline + Hydromorphone Maggiore
Domande frequenti
Can I take Eluxadoline with Morphine?
MediHelp rates the interaction as major. Eluxadoline and Morphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS and is labeled to be avoided with drugs that cause constipation. Morphine's constipating effect may lead to severe constipation or complications such as ileus, and eluxadoline-related pancreatitis risk is also a concern.
How serious is the interaction between Eluxadoline and Morphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if opioid therapy is needed, stop eluxadoline. Monitor for constipation and abdominal pain if exposure overlaps.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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