Interazioni tra farmaci
Midazolam + Sodium oxybate
Gravità: Controindicata
Midazolam and Sodium oxybate: contraindicated interaction.
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Sintesi
Both drugs depress the CNS, and combined use may cause profound sedation, respiratory depression, coma and death. Sodium oxybate labeling advises against use with other CNS depressants.
Cosa significa questa interazione in parole semplici
Midazolam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Midazolam belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
Perché avviene
Additive CNS and respiratory depression via GABAergic mechanisms.
Cosa fare
Avoid combined use; if a sedative is essential, choose a non-CNS-depressant alternative or stop one agent. If unavoidable, use minimal doses with continuous respiratory monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Midazolam
- Atazanavir + Midazolam Controindicata
- Cobicistat + Midazolam Controindicata
- Darunavir + Midazolam Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Controindicata
- Fosamprenavir + Midazolam Controindicata
- Indinavir + Midazolam Controindicata
Altre interazioni di Sodium oxybate
- Alprazolam + Sodium oxybate Controindicata
- Amobarbital + Sodium oxybate Controindicata
- Butorphanol + Sodium oxybate Controindicata
- Chloral hydrate + Sodium oxybate Controindicata
- Clonazepam + Sodium oxybate Controindicata
- Clorazepate + Sodium oxybate Controindicata
Domande frequenti
Can I take Midazolam with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Midazolam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs depress the CNS, and combined use may cause profound sedation, respiratory depression, coma and death. Sodium oxybate labeling advises against use with other CNS depressants.
How serious is the interaction between Midazolam and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use; if a sedative is essential, choose a non-CNS-depressant alternative or stop one agent. If unavoidable, use minimal doses with continuous respiratory monitoring.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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