Interazioni tra farmaci
Methadone + Sodium oxybate
Gravità: Controindicata
Methadone and Sodium oxybate: contraindicated interaction.
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Sintesi
Both drugs depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma and death. Sodium oxybate labeling warns against use with other CNS depressants.
Cosa significa questa interazione in parole semplici
Methadone and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methadone belongs to Musculoskeletal; Sodium oxybate belongs to Central Nervous System.
Perché avviene
Additive CNS and respiratory depression through pharmacodynamic synergism.
Cosa fare
Avoid the combination; use alternative therapy for one of the drugs. If it is unavoidable, use the lowest doses for the shortest time and monitor closely for sedation and respiratory depression.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Methadone
- Alvimopan + Methadone Controindicata
- Calcium / magnesium / potassium / sodium oxybates + Methadone Controindicata
- Droperidol + Methadone Controindicata
- Ibutilide + Methadone Controindicata
- Isocarboxazid + Methadone Controindicata
- Lefamulin + Methadone Controindicata
Altre interazioni di Sodium oxybate
- Alprazolam + Sodium oxybate Controindicata
- Amobarbital + Sodium oxybate Controindicata
- Butorphanol + Sodium oxybate Controindicata
- Chloral hydrate + Sodium oxybate Controindicata
- Clonazepam + Sodium oxybate Controindicata
- Clorazepate + Sodium oxybate Controindicata
Domande frequenti
Can I take Methadone with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Methadone and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma and death. Sodium oxybate labeling warns against use with other CNS depressants.
How serious is the interaction between Methadone and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use alternative therapy for one of the drugs. If it is unavoidable, use the lowest doses for the shortest time and monitor closely for sedation and respiratory depression.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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