Riferimento farmaci
Vandetanib
Vandetanib is a medicine in the class oncology. It is used for thyroid cancer.
- Classe del farmaco: Oncology
- Indicato per: thyroid cancer
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Oncology
- Forme farmaceutiche comuni
- compressa
- Interazioni note
- 137 (Controindicata: 42 · Maggiore: 71 · Moderata: 20 · Minore: 4)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Vandetanib inhibits the tyrosine kinase activity of the EGFR and VEGFR families, RET, BRK, TIE2, and members of the EPH receptor and Src kinase families.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Medullary thyroid cancer (symptomatic or progressive, unresectable locally advanced or metastatic): 300 mg orally once daily until disease progression or unacceptable toxicity
Gravidanza e allattamento
- Gravidanza
- Unsafe Can cause fetal harm; no human data. Embryotoxic, fetotoxic and caused fetal malformations in rats. Verify pregnancy status before starting and use effective contraception.
- Allattamento
- Unsafe No human milk data; present in rat milk. Advise not to breastfeed during treatment and for 4 months after the last dose.
Effetti indesiderati segnalati
- Diarrhea/colitis
- Rash
- Acneiform dermatitis
- Hypertension
- Nausea
- Headache
Avvertenze in evidenza
- Can prolong the QT interval; torsades de pointes and sudden death have occurred. Do not use in patients with hypocalcemia, hypokalemia, hypomagnesemia, or long QT syndrome. Correct hypocalcemia, hypokalemia and/or hypomagnesemia before administration, monitor electrolytes periodically, and avoid drugs known to prolong the QT interval.
Controindicazioni
- Congenital long QT syndrome
Chi deve prestare attenzione
- QT prolongation: do not start if QTcF >450 ms; obtain ECG and potassium, calcium, magnesium and TSH at baseline, 2 to 4 weeks, 8 to 12 weeks, then every 3 months.
- Severe, sometimes fatal skin reactions including TEN and Stevens-Johnson syndrome; permanently discontinue for severe reactions. Photosensitivity can occur up to 4 months after discontinuation.
- Interstitial lung disease/pneumonitis, including fatalities; discontinue if confirmed.
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Interazioni principali (137)
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
- Chlorpromazine + Vandetanib Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Citalopram + Vandetanib Contraindicated
- Clomipramine + Vandetanib Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Vandetanib used for?
Vandetanib is a medicine in the class oncology. It is used for Thyroid cancer.
What side effects have been reported with Vandetanib?
Diarrhea/colitis, Rash, Acneiform dermatitis, Hypertension, Nausea, Headache. Serious warning: Can prolong the QT interval; torsades de pointes and sudden death have occurred.
Can Vandetanib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; no human data. Embryotoxic, fetotoxic and caused fetal malformations in rats. Verify pregnancy status before starting and use effective contraception. Breastfeeding: Unsafe. No human milk data; present in rat milk. Advise not to breastfeed during treatment and for 4 months after the last dose.
What does Vandetanib interact with?
MediHelp lists 137 known interactions for Vandetanib. Contraindicated: 42 · Major: 71 · Moderate: 20 · Minor: 4. The most serious include Amiodarone, Amisulpride, Amitriptyline.
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