Interazioni tra farmaci
Clomipramine + Vandetanib
Gravità: Controindicata
Clomipramine and Vandetanib: contraindicated interaction.
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Sintesi
Vandetanib markedly prolongs the QT interval and has a boxed warning for torsades de pointes. Adding clomipramine, which also prolongs QT, further raises the risk of life-threatening arrhythmia.
Cosa significa questa interazione in parole semplici
Clomipramine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clomipramine belongs to Central Nervous System; Vandetanib belongs to Oncology.
Perché avviene
Additive prolongation of cardiac repolarization.
Cosa fare
Avoid the combination and choose a non-QT-prolonging antidepressant. If unavoidable, use frequent ECG and electrolyte monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clomipramine
- Arsenic trioxide + Clomipramine Controindicata
- Clomipramine + Dofetilide Controindicata
- Clomipramine + Droperidol Controindicata
- Clomipramine + Isocarboxazid Controindicata
- Clomipramine + Methylene blue Controindicata
- Clomipramine + Pentamidine Controindicata
Altre interazioni di Vandetanib
- Amiodarone + Vandetanib Controindicata
- Amisulpride + Vandetanib Controindicata
- Amitriptyline + Vandetanib Controindicata
- Anagrelide + Vandetanib Controindicata
- Asenapine + Vandetanib Controindicata
- Chloroquine + Vandetanib Controindicata
Domande frequenti
Can I take Clomipramine with Vandetanib?
MediHelp rates the interaction as contraindicated. Clomipramine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib markedly prolongs the QT interval and has a boxed warning for torsades de pointes. Adding clomipramine, which also prolongs QT, further raises the risk of life-threatening arrhythmia.
How serious is the interaction between Clomipramine and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antidepressant. If unavoidable, use frequent ECG and electrolyte monitoring.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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