Interazioni tra farmaci
Amiodarone + Vandetanib
Gravità: Controindicata
Amiodarone and Vandetanib: contraindicated interaction.
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Sintesi
Vandetanib markedly prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. With amiodarone, whose half-life is very long, the risk of torsades de pointes and sudden death is significantly increased.
Cosa significa questa interazione in parole semplici
Amiodarone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Vandetanib belongs to Oncology.
Perché avviene
Additive QT prolongation through repolarizing potassium channel blockade.
Cosa fare
Avoid the combination and choose an alternative therapy. Do not start vandetanib while amiodarone is still present in the body unless benefits clearly outweigh risks, with close ECG and electrolyte monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Amiodarone
- Amiodarone + Amisulpride Controindicata
- Amiodarone + Arsenic trioxide Controindicata
- Amiodarone + Dofetilide Controindicata
- Amiodarone + Dronedarone Controindicata
- Amiodarone + Droperidol Controindicata
- Amiodarone + Eliglustat Controindicata
Altre interazioni di Vandetanib
- Amisulpride + Vandetanib Controindicata
- Amitriptyline + Vandetanib Controindicata
- Anagrelide + Vandetanib Controindicata
- Asenapine + Vandetanib Controindicata
- Chloroquine + Vandetanib Controindicata
- Chlorpromazine + Vandetanib Controindicata
Domande frequenti
Can I take Amiodarone with Vandetanib?
MediHelp rates the interaction as contraindicated. Amiodarone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib markedly prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. With amiodarone, whose half-life is very long, the risk of torsades de pointes and sudden death is significantly increased.
How serious is the interaction between Amiodarone and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative therapy. Do not start vandetanib while amiodarone is still present in the body unless benefits clearly outweigh risks, with close ECG and electrolyte monitoring.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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