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Interazioni tra farmaci

Amisulpride + Vandetanib

Gravità: Controindicata

Amisulpride and Vandetanib: contraindicated interaction.

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Sintesi

Vandetanib has a boxed warning for QT prolongation, torsades de pointes, and sudden death, and its use with other QT-prolonging drugs is to be avoided. Amisulpride would add to this risk.

Cosa significa questa interazione in parole semplici

Amisulpride and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amisulpride belongs to Central Nervous System; Vandetanib belongs to Oncology.

Livello di evidenza: High

Perché avviene

Additive QT prolongation through delayed cardiac repolarization.

Cosa fare

Do not combine; use a non-QT-prolonging alternative to amisulpride. If vandetanib treatment is essential, stop amisulpride.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amisulpride with Vandetanib?

MediHelp rates the interaction as contraindicated. Amisulpride and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib has a boxed warning for QT prolongation, torsades de pointes, and sudden death, and its use with other QT-prolonging drugs is to be avoided. Amisulpride would add to this risk.

How serious is the interaction between Amisulpride and Vandetanib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging alternative to amisulpride. If vandetanib treatment is essential, stop amisulpride.

What other medicines interact with Amisulpride?

MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.

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