Interazioni tra farmaci
Chlorpromazine + Vandetanib
Gravità: Controindicata
Chlorpromazine and Vandetanib: contraindicated interaction.
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Sintesi
Vandetanib causes marked, dose-related QT prolongation and has a boxed warning for torsades de pointes and sudden death. Adding chlorpromazine, which also prolongs QT, further increases this risk.
Cosa significa questa interazione in parole semplici
Chlorpromazine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chlorpromazine belongs to Central Nervous System; Vandetanib belongs to Oncology.
Perché avviene
Additive blockade of cardiac potassium channels leading to QT prolongation.
Cosa fare
Avoid concurrent use and choose a non-QT-prolonging alternative to chlorpromazine. If it cannot be avoided, perform frequent ECG monitoring and keep potassium, magnesium and calcium normal.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Chlorpromazine
- Chlorpromazine + Dofetilide Controindicata
- Chlorpromazine + Dronedarone Controindicata
- Chlorpromazine + Droperidol Controindicata
- Chlorpromazine + Ibutilide Controindicata
- Chlorpromazine + Metrizamide Controindicata
- Chlorpromazine + Panobinostat Controindicata
Altre interazioni di Vandetanib
- Amiodarone + Vandetanib Controindicata
- Amisulpride + Vandetanib Controindicata
- Amitriptyline + Vandetanib Controindicata
- Anagrelide + Vandetanib Controindicata
- Asenapine + Vandetanib Controindicata
- Chloroquine + Vandetanib Controindicata
Domande frequenti
Can I take Chlorpromazine with Vandetanib?
MediHelp rates the interaction as contraindicated. Chlorpromazine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib causes marked, dose-related QT prolongation and has a boxed warning for torsades de pointes and sudden death. Adding chlorpromazine, which also prolongs QT, further increases this risk.
How serious is the interaction between Chlorpromazine and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging alternative to chlorpromazine. If it cannot be avoided, perform frequent ECG monitoring and keep potassium, magnesium and calcium normal.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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