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Interazioni tra farmaci

Amikacin + Cefaclor

Gravità: Minore

Amikacin and Cefaclor: minor interaction.

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Sintesi

Cefaclor given with amikacin may add to the risk of kidney injury, particularly in patients with renal impairment or volume depletion. Amikacin is the principal nephrotoxic and ototoxic drug, and reduced renal function increases its exposure. Oral cefaclor is only weakly nephrotoxic.

Cosa significa questa interazione in parole semplici

Amikacin and Cefaclor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Amikacin belongs to Anti Bacterial; Cefaclor belongs to Anti Bacterial.

Livello di evidenza: Low

Perché avviene

Possible additive nephrotoxic potential; evidence for cefaclor is weak.

Cosa fare

Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose for renal function.

Cosa chiedere al farmacista

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amikacin with Cefaclor?

MediHelp rates the interaction as minor. Amikacin and Cefaclor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefaclor given with amikacin may add to the risk of kidney injury, particularly in patients with renal impairment or volume depletion. Amikacin is the principal nephrotoxic and ototoxic drug, and reduced renal function increases its exposure. Oral cefaclor is only weakly nephrotoxic.

How serious is the interaction between Amikacin and Cefaclor?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose for renal function.

What other medicines interact with Cefaclor?

MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.

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