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Amlodipine-olmesartan-hydrochlorothiazide + Chlorothiazide

Gravità: Maggiore

Amlodipine-olmesartan-hydrochlorothiazide and Chlorothiazide: major interaction.

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Il contenuto clinico di questa pagina è disponibile solo in inglese.

Sintesi

This duplicates thiazide therapy since hydrochlorothiazide is already present. Together they raise the risk of hypokalemia, hyponatremia, hypotension, volume depletion and hyperuricemia.

Cosa significa questa interazione in parole semplici

Amlodipine-olmesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.

Livello di evidenza: Moderate

Perché avviene

Additive inhibition of the distal tubule sodium-chloride cotransporter leading to excessive diuresis and electrolyte loss.

Cosa fare

Avoid concurrent use of two thiazides and stop one agent. If unavoidable, monitor electrolytes, renal function and blood pressure closely.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amlodipine-olmesartan-hydrochlorothiazide with Chlorothiazide?

MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This duplicates thiazide therapy since hydrochlorothiazide is already present. Together they raise the risk of hypokalemia, hyponatremia, hypotension, volume depletion and hyperuricemia.

How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Chlorothiazide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides and stop one agent. If unavoidable, monitor electrolytes, renal function and blood pressure closely.

What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?

MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.

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