Interazioni tra farmaci
Chlorothiazide + Hydrochlorothiazide-losartan
Gravità: Maggiore
Chlorothiazide and Hydrochlorothiazide-losartan: major interaction.
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Sintesi
Using chlorothiazide with a hydrochlorothiazide-containing product duplicates thiazide therapy, increasing the risk of hypokalemia, hyponatremia, volume depletion and hypotension without clear added benefit.
Cosa significa questa interazione in parole semplici
Chlorothiazide and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Perché avviene
Duplicate inhibition of the distal tubule sodium-chloride cotransporter giving additive diuresis and electrolyte loss.
Cosa fare
Avoid combining two thiazides and discontinue one. If unavoidable, monitor electrolytes, renal function and blood pressure.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Controindicata
- Dofetilide + Hydrochlorothiazide-losartan Controindicata
- Hydrochlorothiazide-losartan + Sparsentan Controindicata
- Aceclofenac + Hydrochlorothiazide-losartan Maggiore
- Aldesleukin + Hydrochlorothiazide-losartan Maggiore
- Amifostine + Hydrochlorothiazide-losartan Maggiore
Altre interazioni di Chlorothiazide
Domande frequenti
Can I take Chlorothiazide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as major. Chlorothiazide and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using chlorothiazide with a hydrochlorothiazide-containing product duplicates thiazide therapy, increasing the risk of hypokalemia, hyponatremia, volume depletion and hypotension without clear added benefit.
How serious is the interaction between Chlorothiazide and Hydrochlorothiazide-losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides and discontinue one. If unavoidable, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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