Interazioni tra farmaci
Candesartan-hydrochlorothiazide + Chlorothiazide
Gravità: Maggiore
Candesartan-hydrochlorothiazide and Chlorothiazide: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Chlorothiazide duplicates the thiazide component already present in the combination product. This raises the risk of hypokalemia, hyponatremia, volume depletion, hypotension and renal impairment without clear added benefit.
Cosa significa questa interazione in parole semplici
Candesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Perché avviene
Additive diuretic and electrolyte effects of two thiazide diuretics at the distal tubule.
Cosa fare
Avoid concurrent use of two thiazides and stop one. Monitor electrolytes and renal function if the combination cannot be avoided.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Candesartan-hydrochlorothiazide e Chlorothiazide, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Controindicata
- Candesartan-hydrochlorothiazide + Dofetilide Controindicata
- Candesartan-hydrochlorothiazide + Sparsentan Controindicata
- Acemetacin + Candesartan-hydrochlorothiazide Maggiore
- Amifostine + Candesartan-hydrochlorothiazide Maggiore
- Amiloride + Candesartan-hydrochlorothiazide Maggiore
Altre interazioni di Chlorothiazide
Domande frequenti
Can I take Candesartan-hydrochlorothiazide with Chlorothiazide?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorothiazide duplicates the thiazide component already present in the combination product. This raises the risk of hypokalemia, hyponatremia, volume depletion, hypotension and renal impairment without clear added benefit.
How serious is the interaction between Candesartan-hydrochlorothiazide and Chlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides and stop one. Monitor electrolytes and renal function if the combination cannot be avoided.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
