Interazioni tra farmaci
Chlorothiazide + Hydrochlorothiazide-lisinopril
Gravità: Maggiore
Chlorothiazide and Hydrochlorothiazide-lisinopril: major interaction.
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Sintesi
Chlorothiazide duplicates the thiazide component already present and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without added benefit.
Cosa significa questa interazione in parole semplici
Chlorothiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Perché avviene
Duplicate inhibition of the distal tubule sodium-chloride cotransporter with additive electrolyte loss and volume depletion.
Cosa fare
Avoid combining two thiazides and discontinue one. Monitor electrolytes and renal function if overlap is unavoidable.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Controindicata
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Controindicata
- Amifostine + Hydrochlorothiazide-lisinopril Maggiore
- Amiloride + Hydrochlorothiazide-lisinopril Maggiore
- Benazepril + Hydrochlorothiazide-lisinopril Maggiore
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Maggiore
Altre interazioni di Chlorothiazide
Domande frequenti
Can I take Chlorothiazide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Chlorothiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorothiazide duplicates the thiazide component already present and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without added benefit.
How serious is the interaction between Chlorothiazide and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides and discontinue one. Monitor electrolytes and renal function if overlap is unavoidable.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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