Interazioni tra farmaci
Apraclonidine + Selegiline
Gravità: Maggiore
Apraclonidine and Selegiline: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Apraclonidine is an alpha-2 agonist, and labeling advises against its use with MAO inhibitors because of a possible rise in blood pressure. The pharmacological basis is not fully clear, and exposure is low with ophthalmic use, but the labeling warning remains.
Cosa significa questa interazione in parole semplici
Apraclonidine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Selegiline belongs to Central Nervous System.
Perché avviene
Mechanism is not established; possible altered catecholamine handling with MAO inhibition affecting blood pressure.
Cosa fare
Avoid the combination where possible and choose another ocular hypotensive agent. If apraclonidine is essential, monitor blood pressure closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Apraclonidine e Selegiline, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Selegiline
- Amitriptyline + Selegiline Controindicata
- Amoxapine + Selegiline Controindicata
- Atomoxetine + Selegiline Controindicata
- Benzphetamine + Selegiline Controindicata
- Brimonidine + Selegiline Controindicata
- Buprenorphine long-acting + Selegiline Controindicata
Altre interazioni di Apraclonidine
- Apraclonidine + Isocarboxazid Controindicata
- Apraclonidine + Linezolid Maggiore
- Apraclonidine + Phenelzine Maggiore
- Apraclonidine + Rasagiline Maggiore
- Apraclonidine + Tranylcypromine Maggiore
Domande frequenti
Can I take Apraclonidine with Selegiline?
MediHelp rates the interaction as major. Apraclonidine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine is an alpha-2 agonist, and labeling advises against its use with MAO inhibitors because of a possible rise in blood pressure. The pharmacological basis is not fully clear, and exposure is low with ophthalmic use, but the labeling warning remains.
How serious is the interaction between Apraclonidine and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another ocular hypotensive agent. If apraclonidine is essential, monitor blood pressure closely.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
