Interazioni tra farmaci
Artemether + Posaconazole
Gravità: Controindicata
Artemether and Posaconazole: contraindicated interaction.
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Sintesi
Both drugs can prolong the QT interval, and posaconazole may also increase artemether exposure. Together they raise the risk of torsades de pointes.
Cosa significa questa interazione in parole semplici
Artemether and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive QT prolongation, plus CYP3A4 inhibition by posaconazole increasing artemether levels.
Cosa fare
Avoid the combination; use a different antimalarial or antifungal. If unavoidable, obtain a baseline ECG and correct potassium and magnesium.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Posaconazole
- Avanafil + Posaconazole Controindicata
- Cobimetinib + Posaconazole Controindicata
- Conivaptan + Posaconazole Controindicata
- Dihydroergotamine intranasal + Posaconazole Controindicata
- Dihydroergotamine + Posaconazole Controindicata
- Dronedarone + Posaconazole Controindicata
Domande frequenti
Can I take Artemether with Posaconazole?
MediHelp rates the interaction as contraindicated. Artemether and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and posaconazole may also increase artemether exposure. Together they raise the risk of torsades de pointes.
How serious is the interaction between Artemether and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a different antimalarial or antifungal. If unavoidable, obtain a baseline ECG and correct potassium and magnesium.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Avanafil, Cobimetinib, Conivaptan. The full list is on the Posaconazole page.
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