Interazioni tra farmaci
Dihydroergotamine + Posaconazole
Gravità: Controindicata
Dihydroergotamine and Posaconazole: contraindicated interaction.
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Sintesi
Posaconazole markedly raises dihydroergotamine exposure. This can cause ergotism with severe peripheral and cerebral vasospasm and ischemia of the limbs, bowel or brain.
Cosa significa questa interazione in parole semplici
Dihydroergotamine and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Perché avviene
Posaconazole strongly inhibits CYP3A4, the main metabolic pathway of dihydroergotamine.
Cosa fare
Do not co-administer; this is a labeled contraindication. Use a non-ergot migraine treatment while on posaconazole.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Posaconazole
- Artemether + Posaconazole Controindicata
- Avanafil + Posaconazole Controindicata
- Cobimetinib + Posaconazole Controindicata
- Conivaptan + Posaconazole Controindicata
- Dihydroergotamine intranasal + Posaconazole Controindicata
- Dronedarone + Posaconazole Controindicata
Altre interazioni di Dihydroergotamine
- Almotriptan + Dihydroergotamine Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
- Dihydroergotamine + Dopamine Controindicata
- Dihydroergotamine + Dronedarone Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Dihydroergotamine + Eletriptan Controindicata
Domande frequenti
Can I take Dihydroergotamine with Posaconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole markedly raises dihydroergotamine exposure. This can cause ergotism with severe peripheral and cerebral vasospasm and ischemia of the limbs, bowel or brain.
How serious is the interaction between Dihydroergotamine and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; this is a labeled contraindication. Use a non-ergot migraine treatment while on posaconazole.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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