Interazioni tra farmaci
Dihydroergotamine intranasal + Posaconazole
Gravità: Controindicata
Dihydroergotamine intranasal and Posaconazole: contraindicated interaction.
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Sintesi
Posaconazole can substantially increase systemic dihydroergotamine levels after intranasal dosing. This raises the risk of serious vasospastic ischemia of the extremities and central nervous system.
Cosa significa questa interazione in parole semplici
Dihydroergotamine intranasal and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Posaconazole strongly inhibits CYP3A4-mediated clearance of dihydroergotamine.
Cosa fare
Avoid the combination; it is contraindicated in labeling. Choose a non-ergot acute migraine therapy during posaconazole treatment.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Posaconazole
- Artemether + Posaconazole Controindicata
- Avanafil + Posaconazole Controindicata
- Cobimetinib + Posaconazole Controindicata
- Conivaptan + Posaconazole Controindicata
- Dihydroergotamine + Posaconazole Controindicata
- Dronedarone + Posaconazole Controindicata
Domande frequenti
Can I take Dihydroergotamine intranasal with Posaconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole can substantially increase systemic dihydroergotamine levels after intranasal dosing. This raises the risk of serious vasospastic ischemia of the extremities and central nervous system.
How serious is the interaction between Dihydroergotamine intranasal and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; it is contraindicated in labeling. Choose a non-ergot acute migraine therapy during posaconazole treatment.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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