Interazioni tra farmaci
Benazepril + Bismuth subsalicylate
Gravità: Moderata
Benazepril and Bismuth subsalicylate: moderate interaction.
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Sintesi
Salicylate absorbed from bismuth subsalicylate can blunt the blood pressure lowering effect of ACE inhibitors and may add to renal risk, especially in volume depletion, such as during diarrhea. Acute kidney injury is a concern in dehydrated or older patients.
Cosa significa questa interazione in parole semplici
Benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Bismuth subsalicylate belongs to Gastrointestinal Tract.
Perché avviene
Salicylate-mediated inhibition of renal prostaglandins reduces vasodilation and renal perfusion, antagonizing ACE inhibitor effects.
Cosa fare
Avoid regular or prolonged use of bismuth subsalicylate. In dehydrated patients monitor renal function, potassium and blood pressure.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Maggiore
- Bismuth subsalicylate + Warfarin Maggiore
- Acetylsalicylic acid + Bismuth subsalicylate Moderata
- Amlodipine-benazepril + Bismuth subsalicylate Moderata
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderata
- Aspirin rectal + Bismuth subsalicylate Moderata
Altre interazioni di Benazepril
- Aliskiren + Benazepril Controindicata
- Benazepril + Sacubitril / valsartan Controindicata
- Benazepril + Sacubitril-valsartan Controindicata
- Amifostine + Benazepril Maggiore
- Amiloride + Benazepril Maggiore
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Maggiore
Domande frequenti
Can I take Benazepril with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Benazepril and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylate absorbed from bismuth subsalicylate can blunt the blood pressure lowering effect of ACE inhibitors and may add to renal risk, especially in volume depletion, such as during diarrhea. Acute kidney injury is a concern in dehydrated or older patients.
How serious is the interaction between Benazepril and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular or prolonged use of bismuth subsalicylate. In dehydrated patients monitor renal function, potassium and blood pressure.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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