Interazioni tra farmaci
Bupropion + Theophylline
Gravità: Maggiore
Bupropion and Theophylline: major interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Both theophylline and bupropion lower the seizure threshold, so combined use increases the risk of seizures. This is particularly relevant when theophylline levels are elevated or bupropion doses are high.
Cosa significa questa interazione in parole semplici
Bupropion and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Theophylline belongs to Respiratory.
Perché avviene
Additive pharmacodynamic lowering of the seizure threshold.
Cosa fare
Avoid the combination when possible, or use the lowest effective bupropion dose with gradual titration. Keep theophylline levels within the therapeutic range and avoid in patients with other seizure risk factors.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Riferimenti
- buPropion Hydrochloride XL - FDA drug label (DailyMed) — openFDA / DailyMed
Altre interazioni di Theophylline
- Riociguat + Theophylline Controindicata
- Adenosine + Theophylline Maggiore
- Apalutamide + Theophylline Maggiore
- Carvedilol + Theophylline Maggiore
- Cimetidine + Theophylline Maggiore
- Ciprofloxacin + Theophylline Maggiore
Altre interazioni di Bupropion
- Bupropion + Isocarboxazid Controindicata
- Bupropion + Linezolid Controindicata
- Bupropion + Phenelzine Controindicata
- Bupropion + Rasagiline Controindicata
- Bupropion + Selegiline Controindicata
- Bupropion + Selegiline transdermal Controindicata
Domande frequenti
Can I take Bupropion with Theophylline?
MediHelp rates the interaction as major. Bupropion and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both theophylline and bupropion lower the seizure threshold, so combined use increases the risk of seizures. This is particularly relevant when theophylline levels are elevated or bupropion doses are high.
How serious is the interaction between Bupropion and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, or use the lowest effective bupropion dose with gradual titration. Keep theophylline levels within the therapeutic range and avoid in patients with other seizure risk factors.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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