Interazioni tra farmaci
Riociguat + Theophylline
Gravità: Controindicata
Riociguat and Theophylline: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Riociguat is contraindicated with PDE inhibitors including nonspecific ones such as theophylline and dipyridamole. Combining them can cause additive vasodilation with symptomatic hypotension through increased cGMP signalling.
Cosa significa questa interazione in parole semplici
Riociguat and Theophylline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Riociguat belongs to Cardiovascular; Theophylline belongs to Respiratory.
Perché avviene
Additive increases in cGMP: riociguat stimulates soluble guanylate cyclase while theophylline inhibits phosphodiesterases.
Cosa fare
Do not use together. Choose an alternative bronchodilator, or if theophylline is essential discuss options with the specialist and avoid riociguat.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
- Adempas - FDA drug label (DailyMed) — openFDA / DailyMed
Altre interazioni di Theophylline
- Adenosine + Theophylline Maggiore
- Apalutamide + Theophylline Maggiore
- Bupropion + Theophylline Maggiore
- Carvedilol + Theophylline Maggiore
- Cimetidine + Theophylline Maggiore
- Ciprofloxacin + Theophylline Maggiore
Altre interazioni di Riociguat
- Avanafil + Riociguat Controindicata
- Dipyridamole + Riociguat Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide mononitrate + Riociguat Controindicata
- Nitroglycerin + Riociguat Controindicata
- Riociguat + Sildenafil Controindicata
Domande frequenti
Can I take Riociguat with Theophylline?
MediHelp rates the interaction as contraindicated. Riociguat and Theophylline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat is contraindicated with PDE inhibitors including nonspecific ones such as theophylline and dipyridamole. Combining them can cause additive vasodilation with symptomatic hypotension through increased cGMP signalling.
How serious is the interaction between Riociguat and Theophylline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose an alternative bronchodilator, or if theophylline is essential discuss options with the specialist and avoid riociguat.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Adenosine, Apalutamide, Bupropion. The full list is on the Theophylline page.
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