Interazioni tra farmaci
Ciprofloxacin + Theophylline
Gravità: Maggiore
Ciprofloxacin and Theophylline: major interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Ciprofloxacin reduces theophylline clearance and can raise serum theophylline concentrations substantially in some patients. This can lead to nausea, tachycardia, arrhythmias and seizures. Elderly patients, those with high baseline levels, liver disease or heart failure, and smokers who stop are at greater risk.
Cosa significa questa interazione in parole semplici
Ciprofloxacin and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Theophylline belongs to Respiratory.
Perché avviene
Ciprofloxacin inhibits CYP1A2, the main enzyme metabolising theophylline, decreasing its clearance.
Cosa fare
Prefer an antibiotic that does not inhibit CYP1A2. If ciprofloxacin is needed, measure theophylline levels before and during therapy and reduce the theophylline dose empirically.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Riferimenti
Altre interazioni di Theophylline
- Riociguat + Theophylline Controindicata
- Adenosine + Theophylline Maggiore
- Apalutamide + Theophylline Maggiore
- Bupropion + Theophylline Maggiore
- Carvedilol + Theophylline Maggiore
- Cimetidine + Theophylline Maggiore
Altre interazioni di Ciprofloxacin
- Agomelatine + Ciprofloxacin Controindicata
- Ciprofloxacin + Fezolinetant Controindicata
- Ciprofloxacin + Thioridazine Controindicata
- Ciprofloxacin + Tizanidine Controindicata
- Ciprofloxacin + Vandetanib Controindicata
- Alosetron + Ciprofloxacin Maggiore
Domande frequenti
Can I take Ciprofloxacin with Theophylline?
MediHelp rates the interaction as major. Ciprofloxacin and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ciprofloxacin reduces theophylline clearance and can raise serum theophylline concentrations substantially in some patients. This can lead to nausea, tachycardia, arrhythmias and seizures. Elderly patients, those with high baseline levels, liver disease or heart failure, and smokers who stop are at greater risk.
How serious is the interaction between Ciprofloxacin and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If ciprofloxacin is needed, measure theophylline levels before and during therapy and reduce the theophylline dose empirically.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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