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Calcium gluconate + Ceftriaxone

Gravità: Controindicata

Calcium gluconate and Ceftriaxone: contraindicated interaction.

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Sintesi

Ceftriaxone can form insoluble ceftriaxone-calcium salts when it meets calcium-containing solutions. Fatal cases have occurred in neonates with crystalline deposits in the lungs and kidneys. Precipitation can also occur in the infusion line or in the body after separate infusions.

Cosa significa questa interazione in parole semplici

Calcium gluconate and Ceftriaxone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Calcium gluconate belongs to Gastrointestinal Tract; Ceftriaxone belongs to Anti Bacterial.

Livello di evidenza: High

Perché avviene

Ceftriaxone binds calcium to form poorly soluble ceftriaxone-calcium precipitate.

Cosa fare

Never mix or co-infuse ceftriaxone with calcium-containing IV solutions, and in neonates avoid concurrent use entirely. In patients older than 28 days, give sequentially only with thorough line flushing between infusions using a compatible fluid.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Calcium gluconate with Ceftriaxone?

MediHelp rates the interaction as contraindicated. Calcium gluconate and Ceftriaxone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceftriaxone can form insoluble ceftriaxone-calcium salts when it meets calcium-containing solutions. Fatal cases have occurred in neonates with crystalline deposits in the lungs and kidneys. Precipitation can also occur in the infusion line or in the body after separate infusions.

How serious is the interaction between Calcium gluconate and Ceftriaxone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never mix or co-infuse ceftriaxone with calcium-containing IV solutions, and in neonates avoid concurrent use entirely. In patients older than 28 days, give sequentially only with thorough line flushing between infusions using a compatible fluid.

What other medicines interact with Ceftriaxone?

MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium, Lactated ringer's. The full list is on the Ceftriaxone page.

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