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Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate

Gravità: Moderata

Amlodipine-olmesartan-hydrochlorothiazide and Calcium gluconate: moderate interaction.

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Sintesi

Intravenous calcium gluconate can reduce the effect of amlodipine and is used in calcium channel blocker overdose. With thiazides, calcium load can also cause hypercalcemia.

Cosa significa questa interazione in parole semplici

Amlodipine-olmesartan-hydrochlorothiazide and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.

Livello di evidenza: Moderate

Perché avviene

Increased extracellular calcium counteracts L-type calcium channel blockade; thiazide decreases urinary calcium excretion.

Cosa fare

Monitor blood pressure and serum calcium during parenteral calcium therapy and anticipate reduced amlodipine effect.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amlodipine-olmesartan-hydrochlorothiazide with Calcium gluconate?

MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can reduce the effect of amlodipine and is used in calcium channel blocker overdose. With thiazides, calcium load can also cause hypercalcemia.

How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Calcium gluconate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium during parenteral calcium therapy and anticipate reduced amlodipine effect.

What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?

MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.

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