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Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate

Gravità: Moderata

Amlodipine-hydrochlorothiazide-valsartan and Calcium gluconate: moderate interaction.

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Sintesi

Intravenous calcium gluconate can counteract the effects of amlodipine and is used in calcium channel blocker toxicity. Thiazide diuretics also reduce calcium excretion, which may raise serum calcium.

Cosa significa questa interazione in parole semplici

Amlodipine-hydrochlorothiazide-valsartan and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.

Livello di evidenza: Moderate

Perché avviene

Raised extracellular calcium opposes L-type calcium channel blockade; thiazides decrease urinary calcium loss.

Cosa fare

Monitor blood pressure and serum calcium during parenteral calcium administration. Adjust antihypertensive therapy if blood pressure control is lost.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcium gluconate?

MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium gluconate can counteract the effects of amlodipine and is used in calcium channel blocker toxicity. Thiazide diuretics also reduce calcium excretion, which may raise serum calcium.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcium gluconate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium during parenteral calcium administration. Adjust antihypertensive therapy if blood pressure control is lost.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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