Interazioni tra farmaci
Certolizumab pegol + Smallpox vaccine live
Gravità: Controindicata
Certolizumab pegol and Smallpox vaccine live: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Smallpox (vaccinia) vaccine contains replicating live virus that can cause progressive vaccinia in immunosuppressed patients. Certolizumab increases this risk and may reduce vaccine effectiveness.
Cosa significa questa interazione in parole semplici
Certolizumab pegol and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
TNF inhibition impairs cell-mediated control of replicating vaccinia virus.
Cosa fare
Avoid vaccinia vaccine during certolizumab therapy unless risk of smallpox exposure clearly outweighs harm. Consider alternative non-replicating vaccines where available.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Controindicata
- Bcg intravesical live + Certolizumab pegol Controindicata
- Bcg vaccine live + Certolizumab pegol Controindicata
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Controindicata
- Certolizumab pegol + Measles mumps and rubella vaccine Controindicata
- Certolizumab pegol + Measles mumps and rubella vaccine live Controindicata
Domande frequenti
Can I take Certolizumab pegol with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Certolizumab pegol and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Smallpox (vaccinia) vaccine contains replicating live virus that can cause progressive vaccinia in immunosuppressed patients. Certolizumab increases this risk and may reduce vaccine effectiveness.
How serious is the interaction between Certolizumab pegol and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccinia vaccine during certolizumab therapy unless risk of smallpox exposure clearly outweighs harm. Consider alternative non-replicating vaccines where available.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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