Riferimento farmaci
Certolizumab pegol
Certolizumab pegol is a medicine in the class musculoskeletal. It is used for ankylosing spondylitis.
- Classe del farmaco: Musculoskeletal
- Indicato per: ankylosing spondylitis
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Musculoskeletal
- Codice ATC
- L04AB05
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 200 mg, 200 mg/ml
- Interazioni note
- 83 (Controindicata: 13 · Maggiore: 25 · Moderata: 22 · Minore: 23)
- Nomi commerciali
- 5
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
Recombinant humanized antihuman TNF-alpha neutralizing antibody Binds to human TNFα with a KD of 90pM; TNF-alpha is a key pro-inflammatory cytokine with a central role in inflammatory processes
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Crohn Disease (Initial): 400 mg SC (2 injections of 200 mg), repeat at 2 and 4 weeks
Gravidanza e allattamento
- Gravidanza
- Safe Very little crosses the placenta (no Fc region). Data from over 1,500 first-trimester exposures show no rise in birth defects. One of the preferred TNF blockers in pregnancy; can be continued if needed. EU label: delay live vaccines (e.g. BCG) in an exposed infant for 5 months.
- Allattamento
- Safe Milk levels are minimal (CRADLE study) and it is poorly absorbed by the infant. Compatible with breastfeeding.
Effetti indesiderati segnalati
- Headache
- Nasopharyngitis
- URI
- Arthralgia
- Serious infections
Controindicazioni
- History of hypersensitivity reaction to certolizumab pegol or to any of the excipients; reactions have included angioedema, anaphylactoid reaction, serum sickness, and urticaria
Chi deve prestare attenzione
- Increased risk for developing serious infections resulting in hospitalization or death; most patients were taking concomitant immunosuppressants (eg, methotrexate)
- Lymphoma and other malignancies, some fatal, have been reported in children and adolescents treated with TNF blockers.
- Should not receive any live or attenuated vaccines.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (83)
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
- Certolizumab pegol + Measles mumps rubella and varicella vaccine live Contraindicated
- Certolizumab pegol + Rotavirus oral vaccine live Contraindicated
- Certolizumab pegol + Smallpox vaccine live Contraindicated
- Certolizumab pegol + Typhoid vaccine live Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Certolizumab pegol used for?
Certolizumab pegol is a medicine in the class musculoskeletal. It is used for Ankylosing spondylitis, Crohn's disease, Psoriasis, Rheumatoid arthritis, Spondyloarthritis.
What side effects have been reported with Certolizumab pegol?
Headache, Nasopharyngitis, URI, Arthralgia, Serious infections.
Can Certolizumab pegol be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Very little crosses the placenta (no Fc region). Data from over 1,500 first-trimester exposures show no rise in birth defects. One of the preferred TNF blockers in pregnancy; can be continued if needed. EU label: delay live vaccines (e.g. BCG) in an exposed infant for 5 months. Breastfeeding: Safe. Milk levels are minimal (CRADLE study) and it is poorly absorbed by the infant. Compatible with breastfeeding.
What does Certolizumab pegol interact with?
MediHelp lists 83 known interactions for Certolizumab pegol. Contraindicated: 13 · Major: 25 · Moderate: 22 · Minor: 23. The most serious include Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live.
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