Interazioni tra farmaci
Cimetidine + Dasatinib
Gravità: Maggiore
Cimetidine and Dasatinib: major interaction.
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Sintesi
Cimetidine can raise dasatinib exposure through CYP3A4 inhibition, but as an H2 blocker it also lowers gastric acidity, which reduces dasatinib absorption because its solubility depends on acid. The net effect is unpredictable and may result in either toxicity or reduced efficacy.
Cosa significa questa interazione in parole semplici
Cimetidine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Dasatinib belongs to Oncology.
Perché avviene
Weak CYP3A4 inhibition by cimetidine may increase dasatinib levels, while the rise in gastric pH decreases dasatinib dissolution and absorption.
Cosa fare
Avoid H2 blockers with dasatinib; use an antacid given at least 2 hours before or after dasatinib if acid suppression is needed. Monitor response and toxicity if combination cannot be avoided.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Cimetidine
- Cimetidine + Dofetilide Controindicata
- Cimetidine + Fezolinetant Controindicata
- Alfentanil + Cimetidine Maggiore
- Atazanavir + Cimetidine Maggiore
- Carmustine + Cimetidine Maggiore
- Cimetidine + Citalopram Maggiore
Altre interazioni di Dasatinib
- Dasatinib + Saquinavir Controindicata
- Dasatinib + Thioridazine Controindicata
- Adagrasib + Dasatinib Maggiore
- Amiodarone + Dasatinib Maggiore
- Amisulpride + Dasatinib Maggiore
- Amitriptyline + Dasatinib Maggiore
Domande frequenti
Can I take Cimetidine with Dasatinib?
MediHelp rates the interaction as major. Cimetidine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine can raise dasatinib exposure through CYP3A4 inhibition, but as an H2 blocker it also lowers gastric acidity, which reduces dasatinib absorption because its solubility depends on acid. The net effect is unpredictable and may result in either toxicity or reduced efficacy.
How serious is the interaction between Cimetidine and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 blockers with dasatinib; use an antacid given at least 2 hours before or after dasatinib if acid suppression is needed. Monitor response and toxicity if combination cannot be avoided.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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