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Cimetidine + Dofetilide

Gravità: Controindicata

Cimetidine and Dofetilide: contraindicated interaction.

Ultimo aggiornamento Fonti: US FDA label

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Sintesi

Cimetidine increases dofetilide plasma concentrations, with greater effect at higher cimetidine doses, and raises the risk of QT prolongation and torsades de pointes. Dofetilide labeling contraindicates concomitant cimetidine. Patients with renal impairment are especially vulnerable.

Cosa significa questa interazione in parole semplici

Cimetidine and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cimetidine belongs to Gastrointestinal Tract; Dofetilide belongs to Cardiovascular.

Livello di evidenza: High

Perché avviene

Cimetidine inhibits renal tubular cationic secretion (OCT2/MATE) and possibly CYP3A4, reducing dofetilide renal clearance and increasing exposure.

Cosa fare

Do not co-administer. Use an alternative acid suppressant such as a proton pump inhibitor, or famotidine, which is not known to share this effect.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Riferimenti

Domande frequenti

Can I take Cimetidine with Dofetilide?

MediHelp rates the interaction as contraindicated. Cimetidine and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cimetidine increases dofetilide plasma concentrations, with greater effect at higher cimetidine doses, and raises the risk of QT prolongation and torsades de pointes. Dofetilide labeling contraindicates concomitant cimetidine. Patients with renal impairment are especially vulnerable.

How serious is the interaction between Cimetidine and Dofetilide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative acid suppressant such as a proton pump inhibitor, or famotidine, which is not known to share this effect.

What other medicines interact with Dofetilide?

MediHelp also lists interactions of Dofetilide with, for example, Amiodarone, Amisulpride, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Dofetilide page.

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